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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RB1 All Species: 25.76
Human Site: S230 Identified Species: 47.22
UniProt: P06400 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06400 NP_000312.2 928 106159 S230 L D Y F I K L S P P M L L K E
Chimpanzee Pan troglodytes XP_509777 1075 122190 S377 L D Y F I K L S P P V L L K E
Rhesus Macaque Macaca mulatta XP_001100383 928 106126 S230 L D Y F I K L S P P V L L K E
Dog Lupus familis XP_534118 897 103170 K205 L S P P A L L K E P Y K T A V
Cat Felis silvestris
Mouse Mus musculus P13405 921 105320 S224 V D Y F I K F S P P A L L R E
Rat Rattus norvegicus P33568 920 105007 S223 L D Y F I K L S P P A L L R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514098 917 104520 S215 L D Y F I K L S P P A V L K E
Chicken Gallus gallus Q90600 921 104417 S218 L D Y F I K L S P P A M L K E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001071248 903 102339 L216 L E F F A K R L S P S L L Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395096 1006 113492 R214 S N A L L A N R K D L L N P N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790323 774 86478 F95 S N I N I K T F F E H M G K V
Poplar Tree Populus trichocarpa B9GLX8 1035 114624 F257 V P V R F R N F S F N D S Q W
Maize Zea mays Q3LXA7 1010 111475 F240 V P V R L R N F D I K D S S Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.2 99.3 90 N.A. 90.4 89.7 N.A. 81.3 73 N.A. 53.9 N.A. N.A. 23 N.A. 26.4
Protein Similarity: 100 86.3 99.5 93 N.A. 94.9 95.1 N.A. 88.2 84.1 N.A. 70.9 N.A. N.A. 42.9 N.A. 42.6
P-Site Identity: 100 93.3 93.3 20 N.A. 73.3 86.6 N.A. 86.6 86.6 N.A. 40 N.A. N.A. 6.6 N.A. 20
P-Site Similarity: 100 100 100 20 N.A. 86.6 93.3 N.A. 93.3 93.3 N.A. 60 N.A. N.A. 26.6 N.A. 33.3
Percent
Protein Identity: 22.1 23.2 N.A. N.A. N.A. N.A.
Protein Similarity: 40.4 42.1 N.A. N.A. N.A. N.A.
P-Site Identity: 0 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 20 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 16 8 0 0 0 0 31 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 54 0 0 0 0 0 0 8 8 0 16 0 0 0 % D
% Glu: 0 8 0 0 0 0 0 0 8 8 0 0 0 0 54 % E
% Phe: 0 0 8 62 8 0 8 24 8 8 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 8 0 62 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 70 0 8 8 0 8 8 0 47 0 % K
% Leu: 62 0 0 8 16 8 54 8 0 0 8 54 62 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 16 0 0 0 % M
% Asn: 0 16 0 8 0 0 24 0 0 0 8 0 8 0 8 % N
% Pro: 0 16 8 8 0 0 0 0 54 70 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 0 % Q
% Arg: 0 0 0 16 0 16 8 8 0 0 0 0 0 16 0 % R
% Ser: 16 8 0 0 0 0 0 54 16 0 8 0 16 8 8 % S
% Thr: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % T
% Val: 24 0 16 0 0 0 0 0 0 0 16 8 0 0 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 54 0 0 0 0 0 0 0 8 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _